FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM PDF

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Aloe vera has antioxidant, antiinflammatory, healing, antiseptic, anticancer and antidiabetic effects. The aim of the present study was to design and evaluate the formulation of Aloe vera chewing gum with an appropriate taste and quality with the indications for healing oral wounds, such as lichen planus, mouth sores caused by cancer chemotherapy and mouth abscesses as well as reducing mouth dryness caused by chemotherapy. In Aloe vera powder, the carbohydrate content was determined according to mannose and phenolic compounds in terms of gallic acid. Aloe vera powder, sugar, liquid glucose, glycerin, sweeteners and different flavors were added to the soft gum bases.

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Correspondence Address : Dr. Background: Various ginger compounds improve gastrointestinal problems and motion sickness. The main effects of ginger allocate to some phenolics such as gingerols and shogaols that act as their active agents. Chewing gums are among convenient dosage forms which patients prefer due to their advantages.

Hence, this study tried to design, formulate, and evaluate ginger chewing gum of favorable taste and texture to avoid motion sickness and have gastro-protective and anti-oxidant effect. Materials and Methods: Dried ginger rhizomes were percolated to extract ginger compounds. Chewing gums containing 50 mg of concentrated extract were prepared.

Content uniformity, weight variation, release pattern, organoleptic, and mechanical properties were evaluated. Results: Phenolic content was measured Evaluation of organoleptic properties was on 10 healthy volunteers and later prepared formulations exhibited better characteristics. Formulations without any flavorants have higher acceptability. Evaluation of mechanical properties showed higher stiffness of F Conclusion: Ginger chewing gum comprises admissible properties to be used as a modern drug delivery system due to its advantageous results in motion sickness.

It passed all the specified tests for an acceptable chewing gum. Thus, it may be successfully produced to help GI problems. The amazing and mighty ginger. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum ; Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: A systematic review of randomized clinical trials.

Br J Anaesth ; Tiran D. Ginger to reduce nausea and vomiting during pregnancy: Evidence of effectiveness is not the same as proof of safety. Complement Ther Clin Pract ; Toxicol Lett ; Mustafa T, Srivastava KC. Ginger Zingiber officinale in migraine headache. J Ethnopharmacol ; J Pharm Pharmacol ; Anti-ulcerogenic effect of ginger rhizome of Zingiber officinale Roscoe hydroalcoholic extract on acetic acid-induced acute colitis in rats. Res Pharm Sci ; Shukla Y, Singh M. Cancer preventive properties of ginger: A brief review.

Food Chem Toxicol ; Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger Zingiber officinale Roscoe. Molecules ; Synthesis of phenolics and flavonoids in ginger Zingiber officinale Roscoe and their effects on photosynthesis rate.

Int J Mol Sci ; Antioxidant and inhibitory effect of red ginger Zingiber officinale var. Rubra and white ginger Zingiber officinale Roscoe on Fe 2 induced lipid peroxidation in rat brain in vitro. Exp Toxicol Pathol ; Anti-ulcerogenic effect of ginger rhizome of Zingiber officinale Roscoe on cystemine induced duodenal ulcer in rats. Daru J Pharm Sci ; Protective effect of ginger volatile oil against acetic acid-induced colitis in rats: A light microscopic evaluation.

J Integr Med ; Directly compressible medicated chewing gum formulation for quick relief from common cold. Int J Pharm Investig ; Some phytochemical, pharmacological and toxicological properties of ginger Zingiber officinale Roscoe : A review of recent research.

Alternative medicine: Herbal drugs and their critical appraisal — Part II. Prog Drug Res ; Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine ; Mode of action of gingerols and shogaols on 5-HT3 receptors: Binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. Eur J Pharmacol ; Wang H, Ng TB. An antifungal protein from ginger rhizomes. Biochem Biophys Res Commun ; Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks.

Arch Pharm Res ; Medicated chewing gum - A 21 st century drug delivery system. Int J Pharm Sci Res ; Rassing MR. Chewing gum as a drug delivery system.

Adv Drug Deliv Rev ; Imfeld T. Chewing gum — Facts and fiction: A review of gum-chewing and oral health. Crit Rev Oral Biol Med ; Oral dosages form: Medicine containing chewimg gum: A review. J Drug Deliv Ther ;2: Heema N, Stuti G. Medicated chewing gums-updated review. Int J Pharm Res Dev ; Modified-Release Drug Delivery Technology. Smith AP, Woods M.

Effects of chewing gum on the stress and work of university students. Appetite ; European Pharmacopoeia. Development, in-vitro evaluation and physical characterization of medicated chewing gum: Chlorhexidine gluconate.

Der Pharmacia Lettre ; Design, formulation and evaluation of medicinal chewing gum by the extract of Salvadora persica L. Life Sci J ; Aslani A, Rafiei S. Design, formulation and evaluation of nicotine chewing gum.

Adv Biomed Res ; Design, formulation and evaluation of green tea chewing gum. Aslani A, Jalilian F. Design, formulation and evaluation of caffeine chewing gum. Chewing gum: A modern approach to oral mucosal drug delivery. Medicated chewing gum: Modern approach to mucosal drug delivery. Asian J Res Pharm Sci ; Khatun S, Sutradhar KB. Medicated chewing gum: An unconventional drug delivery system.

Int Curr Pharm J ; Waterhouse A. Determination of Total Phenolics. Current Protocols in Food Analytical Chemistry. New York: John Wiley; Makkar HP.

LE CHUCHOTEUR PDF

Formulation, Manufacture and Evaluation of Medicated Chewing Gum

Correspondence Address : Dr. Background: Various ginger compounds improve gastrointestinal problems and motion sickness. The main effects of ginger allocate to some phenolics such as gingerols and shogaols that act as their active agents. Chewing gums are among convenient dosage forms which patients prefer due to their advantages. Hence, this study tried to design, formulate, and evaluate ginger chewing gum of favorable taste and texture to avoid motion sickness and have gastro-protective and anti-oxidant effect. Materials and Methods: Dried ginger rhizomes were percolated to extract ginger compounds.

AGROECOLOGIA GLIESSMAN STEPHEN PDF

Design, formulation and evaluation of Aloe vera chewing gum.

An attempt was made to formulate medicated chewing gum to prevent motion sickness using natural gum base for faster onset of action and easy administration, anywhere and anytime, without access to water. To avoid the discard issue of gum cud, natural gum base of Triticum aestivum wheat grain was explored because of its biodegradable and biocompatible nature and easy availability. Prolamin, extracted from wheat, showed good chewing capacity, elasticity, high water retention capacity, antifungal activity, and compatibility with the drug. Formulations were prepared based on a two-factor and three-level factorial design. Amount of calcium carbonate texturizer and gum base were selected as independent variables. Elasticity and drug release were considered as the dependent variables. All batches were evaluated for the content uniformity, elasticity study, texture study, in vitro drug release study, and chewiness study.

ELSTAT EMS 55 PDF

Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness

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