ELLAGIC ACID FROM POMEGRANATE FILETYPE PDF

There is currently a shifting focus towards finding natural compounds that may prevent or treat cancer, due to the problems that exist with current chemotherapeutic regimens. The fruit of the Punica granatum pomegranate contains hundreds of phytochemicals and pomegranate extracts have recently been shown to exhibit antioxidant properties, thought to be due to the action of ellagic acid, the main polyphenol in pomegranate. In this mini review the effects of pomegranate extracts and ellagic acid on the proliferation of prostate cancer cells and their future potential are discussed. This site needs JavaScript to work properly.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Estrogen is known to affect these considerably so there would be no way to control these effects among female participants in the study.

Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms x. COVID is an emerging, rapidly evolving situation. Save this study. Warning You have reached the maximum number of saved studies Pure Ellagic Acid on Healthy Male Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Last Update Posted : September 20, Study Description. The purpose of this research study is to compare the extent of polyphenol absorption in the body in normal healthy male volunteers when consuming either pomegranate juice or pure ellagic acid, an ellagitannin naturally present in pomegranates. Polyphenols are naturally occurring chemicals found in plant based food that serve to reduce inflammation and damage to cells.

You will be asked to avoid foods rich in polyphenols including dark chocolate and cocoa products, dried herbs, berries, coffee, tea, flaxseeds, nuts chestnut, hazelnut , olive and artichoke. Timed urine collections will be used to measure the metabolism of polyphenols through the presence and concentration of urolithin and ellagic acid metabolites. Additionally, it has been demonstrated in animal studies that fruits and vegetables, which are high in antioxidants and fiber, lead to improvement of gut health, inflammation and glucose tolerance.

However, no information is available about the effect of ellagitanins on the gut microbiome bacteria in the intestines. Detailed Description:.

Based on the limited knowledge about the difference in bacterial metabolism of a mixture of ellagitannins, punicalin, punicalagin and EA in PJ compared to pure EA leading to intestinal formation of different urolithins urolithin A, B and iso-urolithin A , the objective of this study is to perform a cross over acute bioavailability study of 1-day consumption of either PJ or EA.

Primary endpoint will be the formation and bioavailability of EA and urolithins. Arms and Interventions. Volunteers will consume either one dose of pomegranate juice or pure ellagic acid, an ellagitannin naturally present in pomegranates. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Screening laboratory value outside of the laboratory normal range that is considered clinically significant for study participation by the investigator. Subjects will be excluded if there is a prior history of such sensitivity. Since these foods are commonly eaten and allergies are rare, subjects should be aware of this sensitivity prior to entering the study.

In addition, any subject with a history of allergy or anaphylaxis of any kind will be excluded Taking antibiotics or laxatives within the past 3 months. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. Los Angeles, California, United States, More Information.

National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Not Applicable. Study Type :.

Actual Enrollment :. Pure Ellagic Acid. Actual Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Dietary Supplement: Pomegranate Juice Volunteers will consume either one dose of pomegranate juice or pure ellagic acid, an ellagitannin naturally present in pomegranates. Other Name: PJ. Dietary Supplement: Ellagic Acid Volunteers will consume either one dose of pomegranate juice or pure ellagic acid, an ellagitannin naturally present in pomegranates.

Other Name: EA. Females have been excluded from the study to reduce the variability in the endothelial measures and Nitric Oxide determinations being performed after administration of the pomegranate or ellagic acid capsules.

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Benefits of ellagic acid from grapes and pomegranates against colorectal cancer

We admire the authors of above paper for their valuable paper. In this article, it has been explained that in Iran, gastric and colorectal adenocarcinoma are the second and the fifth most common cancers respectively. It is then suggested to increase attention to prevention of colorectal cancer which is very important. On the other hand, almost all people consume fruits as the best and safest way to treatment and elimination of diseases. Fruits such as pomegranates and grapes have remedial purposes. According to the Holy Qur'an, pomegranate and grape grow in the gardens of paradise 1 - 3.

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The Effects of Ellagic Acid From Pomegranate Juice vs. Pure Ellagic Acid on Healthy Male Subjects

Lost password? Your personal data will be used to support your experience throughout this website, to manage access to your account, and for other purposes described in our privacy policy. We know we can get vitamins and minerals from fresh fruits and vegetables, in addition they are also full of other nutrients. This product is designed to complement a daily intake of fruits and vegetables and offers a variety of plant-sourced nutrients in the diet by providing a varierty of phytonutrients from plant sources. Advisory Keep out of reach of young children.

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Ellagic Acid, Pomegranate and Prostate Cancer -- A Mini Review

A different experiment on rats showed that a single component from pomegranate, ellagic acid, was able to counteract the negative effect on semen quality. Bioguided fractionation suggested that gallic acid GA was Pg main active. Pomegranate peel increases type I procollagen synthesis, which was. Amazon Rapids Fun stories for kids on the go. I like this brand but thought this was organic. Chebulagic acid Chebulinic acid.

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Nutrilite Concentrated Fruits and Vegetables

Study record managers: refer to the Data Element Definitions if submitting registration or results information. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Estrogen is known to affect these considerably so there would be no way to control these effects among female participants in the study. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

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