Tumours with oncocytic features. Atlas of tumor pathology. Tumors of the thyroid gland. Giangaspero F, Cenacchi G.
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Click here to learn What's New at our website. Page views in 33, Cite this page: Younes S. Follicular adenoma. Accessed June 5th, Benign tumor that shows evidence of follicular differentiation but lacks evidence of capsular and vascular invasion and lacks papillary carcinoma nuclear features Atypical adenoma : pleomorphism, cellularity, mitotic figures or necrosis but without capsular or vascular invasion; typically considered to have benign behavior but may be precursor of anaplastic carcinoma Hum Pathol ; Clinical features.
Radiology description. Gross description. Solitary, encapsulated, variable size 1 - 10 cm Solid, fleshy, tan to light brown Bulges when fresh, compresses adjacent thyroid Resembles multinodular goiter due to secondary changes of hemorrhage and cystic degeneration.
Contributed by Andrey Bychkov, M. Encapsulated nodule. Grossing and sampling. Contributed by Dr. Mark R. Encapsulated, homogeneous tan cut surface. Bisected adenoma has fresh hemorrhage. Marked necrosis, hemorrhage and cystic change. Marked cystic degeneration. Well circumscribed tumor. Well encapsulated. Central scar. Cystic and partially necrotic tumor. Microscopic histologic description. Microscopic histologic images. Scroll to see all images.
Abundant crystals of calcium oxalate. Calcium oxalate crystals. Processing artifact with distorted nuclei. Tissue degeneration often induces for- mation of vesicular appearing nuclei. Cellular follicular adenoma. Various images. Thin and uniform fibrous capsule. Marked fibrosis and stromal hyalinization. Marked hyaline thickening of vessel walls. Marked fibrosis, hyalinization and calcium deposition. Marked vasculari- zation resembles a vascular neoplasm.
Capsular vessel with smooth muscle cells. Bizarre nuclei. Large, extremely irregular nuclei. With papillary hyperplasia. With papillary hyperplasia and adipose metaplasia. Cartilaginous metaplasia adenochondroma. Toxic adenoma is solitary and unencapsulated.
Prominent clear cell change. Squamous metaplasia. Mucin production. A: solid, B: trabecular, C: microfollicular, D: macrofollicular. Left: macrofollicular, right: solid pattern. Signet ring. Markedly cellular with irregular growth. Well formed follicles merge with solid pattern. Spindle cells mix with round cells. Fine needle induced changes resemble invasion AFIP. Adjacent atrophic follicular epithelium. Clear cell adenoma. Trabecular type. Encapsulated microfollicular adenoma. Microfollicular, trabecular and solid.
Insular fig. Spindle cell type. Cytology description. High cellularity, syncytial 3 dimensional arrangement, prominent nuclear crowding but no papillary nuclear features, minimal colloid Cannot rule out carcinoma based on cytologic findings Not all small groups of follicular cells are consistently classified as microfollicles in FNA, and some are more often classified as macrofollicles Arch Pathol Lab Med ; Cytology images.
Round hyperchromatic nuclei fig. Positive stains. Thyroglobulin Low molecular weight cytokeratin. Negative stains. Electron microscopy images. Microvilli project into well developed lumina. Signet ring follicular adenoma. Histopathology Thyroid - Follicular adenoma microfollicular by John R. Minarcik, M.
Differential diagnosis. Follicular variant of papillary carcinoma : has nuclear features of papillary carcinoma Minimally invasive follicular carcinoma Nodular hyperplasia with dominant nodule : hyperplastic changes elsewhere in gland, often not encapsulated.
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Follicular thyroid adenoma is a commonly found benign neoplasm of the thyroid consisting of differentiated follicular cells. It cannot be differentiated from follicular carcinoma on cytologic, sonographic or clinical features alone 1. Follicular thyroid adenoma is more commonly found in women, increases in incidence with increasing age and in regions in which the diet is iodine deficient 3. Follicular adenomas are encountered approximately 5 times more frequently than follicular carcinomas 2. Macroscopically follicular adenomas are round to oval, with a surrounding fibrous capsule that is usually regular and thin.